Staphylococcal alpha toxin
- Staphylococcal alpha toxin
-
(= leucocidin)
1. Pore-forming exotoxin (33 kD) secreted by
Staphylococcus aureus. Protein (monomer) has two domains connected by flexible hinge region: oligomerises in the
plasma membrane by lateral mobility to form
a hexameric oligomer (220 kD) that has
a pore approximately 1nm in diameter with some anion selectivity. Osmotic
lysis leads to death of the cell. Has been used to selectively permeabilise cells to small molecules.
2. Small peptide exotoxin (26 residues) secreted by
Staphylococcus aureus. Binds to membranes and
a range of cellular components. Very
amphipathic and surface active. Properties, though not sequence, very similar to
melittin
Dictionary of molecular biology.
2004.
Look at other dictionaries:
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