Staphylococcal alpha toxin

Staphylococcal alpha toxin
(= leucocidin)
1. Pore-forming exotoxin (33 kD) secreted by Staphylococcus aureus. Protein (monomer) has two domains connected by flexible hinge region: oligomerises in the plasma membrane by lateral mobility to form a hexameric oligomer (220 kD) that has a pore approximately 1nm in diameter with some anion selectivity. Osmotic lysis leads to death of the cell. Has been used to selectively permeabilise cells to small molecules.
2. Small peptide exotoxin (26 residues) secreted by Staphylococcus aureus. Binds to membranes and a range of cellular components. Very amphipathic and surface active. Properties, though not sequence, very similar to melittin

Dictionary of molecular biology. 2004.

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